49ers vs. Vikings odds, line, spread: Monday Night Football picks, predictions from NFL model on 26-12 run

The San Francisco 49ers will try to bounce back from their first loss when they face the Minnesota Vikings on Monday Night Football. The 49ers (5-1) followed their throttling of Dallas in Week 5 with a dud against the Browns last Sunday. They had a chance to win on a late field goal, but it was pushed wide right and Cleveland won 19-17. The Vikings (2-4) have won two of their past three. They also struggled in Week 5, but managed a 19-13 victory at Soldier Field against the Bears. 49ers receiver (Deebo Samuel) is out with a shoulder injury, while running back Christian McCaffrey is questionable with an oblique injury.

Monday’s kickoff in Minneapolis is set for 8:15 p.m. ET. The latest 49ers vs. Vikings odds list San Francisco as a seven-point favorite, and the over/under for total points scored is 43. Before you make any Vikings vs. 49ers picks, you need to see the NFL predictions and betting advice from SportsLine’s advanced computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 7 of the 2023 NFL season on an incredible 172-120 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 26-12 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated 49ers vs. Vikings 10,000 times and just revealed its coveted NFL picks and predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Vikings vs. 49ers:

Why the 49ers can cover

San Francisco leads the league in scoring defense (14.5 points per game) and ranks second on offense (30.7). Quarterback Brock Purdy is a steady leader, throwing 10 touchdown passes against just one interception. San Francisco leads the NFL in turnover margin at plus-8, while Minnesota is minus-7, third-worst in the league. The San Francisco defense has intercepted 10 passes.

The 49ers have won six straight primetime games (4-2 against the spread) and are 11-2-1 against the number in their past 14 games overall. Receiver Brandon Aiyuk (454 receiving yards) and tight end George Kittle (18 receptions) give Purdy other options with receiver Deebo Samuel (shoulder) out. Linebacker Fred Warner has been a force, with 48 tackles, two sacks and two interceptions. See who to back at SportsLine.

Why the Vikings can cover

Quarterback Kirk Cousins leads the league’s third-most potent passing offense (264 yards per game). The veteran has 1,679 passing yards, 14 touchdown passes and four interceptions. Star receiver Justin Jefferson is out, but Cousins has plenty of other options.

Tight end T.J. Hockenson has become a go-to guy and has 36 receptions, tied for 11th in the league. Receivers Jordan Addison and K.J. Osborn have combined for 491 receiving yards and six scores, and Alexander Mattison has 18 catches out of the backfield. The Vikings’ defense blitzes more than any other team and Purdy averages two yards fewer per attempt against the blitz. Minnesota has 18 sacks, led by Danielle Hunter’s eight, tied for most in the NFL. See who to back at SportsLine.

How to make 49ers vs. Vikings picks

SportsLine’s model is leaning Under the total, projecting 42 combined points. The model also says one side of the spread has all the value. You can only see the model’s NFL picks and analysis at SportsLine. 

So who wins Vikings vs. 49ers on Monday Night Football, and which side of the spread has all the value? Visit SportsLine now to see which side of the Vikings vs. 49ers spread to back, all from the model that has returned well over $7,000 on top-rated NFL picks, and find out.